The use of Blood Concentrates is becoming more and more popular in the industry.
EZ PRF is the result of years of experience and study. Consequently, we’ve found what we think is the ULTIMATE blood concentrate!
Not only does EZPRF contain more platelets per mcL, it also has leukocytes (WBC) & mesenchymal stem cell!
We could also call it the "Platelet, Leukocyte & Mesenchymal-stem-cells Concentrate”, but that would be a bit long, wouldn’t it? (#PLMC)
The fact that the plasma actually clots into fibrin allows for a much slower release of the Growth factor and cytokines.
We have more cells, resulting in more GFs, kept alive longer and released for a much longer period of time.
In order to obtain PRP, it is necessary to spin the tubes at up to 6x the G-Force of the EZPRF process.
The idea of the high spin method is to eliminate all Red Blood Cells (RBC), by pushing them down with gravitational force.
It's a good idea, but spinning it too fast, for too long, PRP methods also eliminate the cells that we DO want.
This is High School Biology: Our tubes are 100% Natural and devoid of any anti-coagulant. As a result, fibrinogen molecules can be converted by thrombin into fibrin during blood clot formation.
We're only using about 1/10th of the volume collected. And because we're spinning at a very low G-Force, the platelet recovery is very close to 100%!
Below, we're explaining why claims of 5x the concentration while using up to 1/2 of the collected volume is mathematically impossible!
There seems to be a debate in the scientific community about the White Blood Cells and their effect on the healing process. You'll get a different conclusion depending on who's financing the study.
We are creating what’s called a controlled inflammatory response and leukocytes are the cells associated with inflammatory response.
When PRP companies measure their platelet concentration, they usually use the bottom of their concentrate, the closest possible to the separating gel.
We've discussed earlier that spinning too fast sends the cells to the bottom. It also creates an imbalanced concentrate. The higher we collect, the less concentrated.
So even if you're still collecting PRP, we'd recommend to use only the bottom 1/3 above the gel (On a 10ml tube, that's about 2cc). Otherwise you're diluting your solution with pure plasma (water)
Let's have some fun with very simple math! :)
There are 20 Sheep in a 10 acre field.
That gives us a concentration of 2 sheep per acre.
Let's push all the sheep to the right 1/2 of the field. This is the equivalent of moving all the platelets on the top 1/2 of the tube.
We now have 4 sheep per acre, which equals to 2x the sheep concentration.
(This is similar to PRP: 1/2 the initial volume = max 2x the concentration)
If we move them all to 1/5 of the field, then we have 10 sheep per acre, which equals to 5x the concentration.
That is when we're able to retain 100% of the sheep (or a sheep recovery of 100%)
Otherwise, you're just creating Platelets (or sheep) out of thin air.
Our proprietary EZPRF tubes and centrifuge settings are designed to create a blood concentrate rich in platelets, leukocytes and Mesenchymal stem cells.
Our offer is very simple, we've got 2 kits. Our first kit, the EZ2K, contains 2 x 13ml tubes for 3 to 6cc of blood concentrate. The other kit, the EZ4k, contains 4 tubes of 13ml and will yield up to10cc.
The EZMINISPIN is the smallest centrifuge on the market capable of hosting up to 6 x 13mL test tubes. It has been pre-configured with our two customized EZPRF settings, and retains the ability to be set manually should the user feel the need to use a different centrifugation speed and time.
Kian Karimi MD, FACS, and Anil Rajani, MD. Cindy J. Papp, Contributing Editor
Shaoheng Xiong, M.D., Lihong Qiu, M.D., Yinjun Su, M.D., Ph.D., Hui Zheng, M.D., Chenggang Yi, M.D., Ph.D.
Balaram Naik, P Karunakar, M Jayadev, and V Rahul Marshal
Soh Nishimoto,corresponding author Kazutoshi Fujita, Yohei Sotsuka, Masato Kinoshita, Toshihiro Fujiwara, Kenichiro Kawai, and Masao Kakibuchi
Kian Karimi, M.D., Helena Rockwell, B.Sc.
Sercan Gode, M.D., Arin Ozturk, M.D., Erkan Kısmalı, M.D., Veysel Berber, M.D., Goksel Turhal, M.D. | Facial Plast Surg | 2019
Sercan Gode, M.D., Arin Ozturk, M.D., Veysel Berber, M.D., Erkan Kısmalı, M.D. | Facial Plast Surg | 2019
Aunna Pourang, M.Da., Helena Rockwell, B.Scb., Kian Karimi, M.Dc. | Facial Plast Surg Clin | 2020
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